Apply ammonium lactate at around the same time (s) every day. Evaluation of ammonium lactate in the treatment of seborrheic keratoses Maria V. Klaus, MD,a Richard F. Wehr, BS,b Roy S. Rogers III, MD,c Thomas J. Russell, MD: and Lincoln Krochmal, MOb Buffalo, New York, Rochester, Minnesota. Animal reproduction studies have been performed in rats and rabbits at doses up to 0.7 and 1.5 times the human dose, respectively (600 mg/kg/day, corresponding to 3600 mg/m2/day in the rat and 7200 mg/m2/day in the rabbit) and have revealed no evidence of impaired fertility or harm to the fetus due to Ammonium Lactate formulations. The oral administration of ammonium lactate to rats and mice showed this drug to be practically non-toxic (LD50>15 mL/kg). It is usually applied to the affected skin area twice daily. The potential for post-inflammatory hypo- or hyperpigmentation has not been studied. Patients using Ammonium Lactate Lotion, 12% should receive the following information and instructions: The topical treatment of CD-1 mice with 12%, 21% or 30% Ammonium Lactate formulations for two-years did not produce a significant increase in dermal or systemic tumors in the absence of increased exposure to ultraviolet radiation. Set id: dc3a6462-0f2c-4306-b5ef-c7b47395e959, Not for Ophthalmic, Oral or Intravaginal Use, 225 g in 1 BOTTLE, PLASTIC; Type 0: Not a Combination Product, 400 g in 1 BOTTLE, PLASTIC; Type 0: Not a Combination Product. Ammonium lactate is usually applied twice a day. The alpha-hydroxy acids (and their salts) may act as humectants when applied to the skin. Available for Android and iOS devices. Rash and peeling skin may also occur. Use twice daily or as directed by a physician. It is a normal constituent of tissues and blood. Ammonium Lactate Lotion, 12% is indicated for the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris, and for the temporary relief of itching associated with these conditions. For lot number and expiration date, see bottle. Because animal reproduction studies are not always predictive of human response, Ammonium Lactate Lotion, 12% should be used during pregnancy only if clearly needed. In dermal Segment I and III studies with Ammonium Lactate formulations there were no effects observed in fertility or pre- or postnatal development parameters in rats at dose levels of 300 mg/kg/day (1800 mg/m2/day), approximately 0.4 times the human topical dose. Usual Dosage: Shake well. Lactic acid is a racemic mixture of 2-hydroxypropanoic acid and has the following structural formula: Lactic acid is an alpha-hydroxy acid, it is a normal constituent of tissues and blood. In general, dose selection for an elderly patient should be cautious. Shake well. Shake well. Last updated on Sep 21, 2020. Safety and effectiveness of ammonium lactate have been demonstrated in infants and children. color white shape No data. Use exactly as directed on the label, or as prescribed by your doctor. * by AmLactin Ammonium Lactate; Third Edition Keep your skin looking smooth, vibrant and healthy with this Ammonium Lactate 12 Percent Cream. No unusual toxic effects were reported. Many lotions and creams sting terribly and cause worse suffering, but Ammonium Lactate cream is so cooling and soothing and does not further irritate my sensitive skin. However, a long-term photocarcinogenicity study in hairless albino mice suggested that topically applied 12% Ammonium Lactate formulations enhanced the rate of ultraviolet light-induced skin tumor formation. But the smell dissipates, and for many, it truly helps heal dry skin. Ammonium Lactate 12% Moisturizing Cream 140 Gm Flip-Top Tube [2 PACK] AMMONIUM LACTATE 12% MOISTURIZING LOTION 226GM (8 OZ) EACH (PACK OF 2) *COMPARE TO THE SAME ACTIVE INGREDIENTS FOUND IN AMLACTIN & SAVE! Use twice daily or as directed by a physician. Lotions are thinner and lighter in consistency and can be used all over the body (for example, in case of eczema). For external use only. This property may influence hydration of the stratum corneum. and Milwaukee, Wisconsin A double-blind, paired comparison study was used to evaluate treatment effects of 12% ammonium lactate lotion (Lac-Hydrin) against its … I've been using it for years, including back when it was only available by prescription here. Shake the lotion form of this medication well just before using it. Ammonium Lactate Lotion, 12% is contraindicated in those patients with a history of hypersensitivity to any of the label ingredients. In general, dose selection for an elderly patient should be cautious. The following image is a placeholder representing the product identifier that is either affixed or imprinted on the drug package label during the packaging operation. Due to the more severe initial skin conditions associated with ichthyosis, there was a higher incidence of transient stinging, burning and erythema (each occurring in 1 in 10 patients). Because many drugs are excreted in human milk, caution should be exercised when ammonium lactate is administered to a nursing woman. There are, however, no adequate and well-controlled studies in pregnant women. No unusual toxic effects were reported. Ammonium Lactate Lotion, 12% is contraindicated in those patients with a history of hypersensitivity to any of the label ingredients. There are, however, no adequate and well-controlled studies in pregnant women. It also contains cetyl alcohol, fragrance, glycerin, glyceryl stearate, laureth-4, light mineral oil, magnesium aluminum silicate, methylcellulose, methylparaben, PEG-100 stearate, polyoxyl 40 stearate, propylene glycol, propylparaben, and purified water. This property may influence hydration of the stratum corneum. In dermal Segment I and III studies with ammonium lactate formulations there were no effects observed in fertility or pre- or postnatal development parameters in rats at dose levels of 300 mg/kg/day (1800 mg/m2/day), approximately 0.4 times the human topical dose. The use of Ammonium Lactate Lotion, 12% should be discontinued if any hypersensitivity is observed. *Ammonium Lactate Lotion, 12% specially formulates 12% lactic acid neutralized with ammonium hydroxide, as Ammonium Lactate to provide a lotion pH of 4.5 - 5.5. The potential for post-inflammatory hypo- or hyperpigmentation has not been studied. Animal reproduction studies have been performed in rats and rabbits at doses up to 0.7 and 1.5 times the human dose, respectively (600 mg/kg/day, corresponding to 3600 mg/m2/day in the rat and 7200 mg/m2/day in the rabbit) and have revealed no evidence of impaired fertility or harm to the fetus due to ammonium lactate formulations. Although lactic acid is a normal constituent of blood and tissues, it is not known to what extent this drug affects normal lactic acid levels in human milk. Ammonium Lactate Lotion, 12% is indicated for the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris, and for the temporary relief of itching associated with these conditions. Apply to the affected areas and rub in thoroughly. For external use only. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. ammonium lactate 12 % topical cream. 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