We conducted a systematic review to define the best therapies for actinic cheilitis in clinical response and recurrences. This is a natural treatment for angular cheilitis. Diagnosis and care are provided by experienced consultants. We first identified 444 papers, and 49 were finally considered, including 789 patients and 843 treated areas. Squamous cell carcinoma is a type of skin cancer. 2008 Sep-Oct;21(5):412-5. doi: 10.1111/j.1529-8019.2008.00224.x. The affected areas become white, scaly, and dry. 2020 Sep;83(3):876-887. doi: 10.1016/j.jaad.2019.07.106. Being a potentially malignant lesion, it is important to seek evidence about the best results found. A number of treatments are available for actinic keratosis, a condition in which too much sun exposure leads to lesions (keratoses) that may become cancerous. eCollection 2020 Oct. J Eur Acad Dermatol Venereol. Photodynamic therapy: treatment of choice for actinic cheilitis? The scientific evidence available on the treatment of AC is scarce and heterogeneous, photodynamic therapy, and imiquimod application are promising. Refrigerate a leaf of aloe vera prior to applying it on the affected area. Stage 3 – Severe Angular Cheilitis. Treatment of Lip Keratoses (Actinic Cheilitis) With Topical Fluorouracil. Interestingly, when combined with 5% imiquimod, the efficacy of PDT was significantly enhanced. Actinic cheilitis is a condition where the outer layer of the lips becomes damaged. Jadotte YT, Schwartz RA. It is a type of ear infection that resembles actinic keratosis of the skin. If there's any doubt, your doctor may do other tests, such as a skin biopsy. When it heals in 1 or 2 weeks, you see new, healthier skin. Actinic cheilitis presents as diffuse or patchy dryness and variable thickening of the vermilion of the lower lip. The study of the treatments for AC in the form of a systematic review allows us to evaluate the results against the different treatments. Angular cheilitis is a condition that causes red, swollen patches in the corners of your mouth where your lips meet and make an angle. Protecting the lips from additional sun exposure with lip balm containing sunscreen or a hat to shade the face helps prevent recurrence of actinic cheilitis. Patients with actinic cheilitis should follow up after treatment with visits at least every six months for the first two years, and annual skin checks after that. This site needs JavaScript to work properly. The line between healthy skin and lipstick is called Vermillion Border. -. Dermatol Ther. doi: 10.1002/14651858.CD004415.pub2. Rodrigues MS, Kaefer EO, Sganzerla JT, Gassen HT, Dos Santos RB, Miguens-Jr SA. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Actinic cheilitis treatment options cover the spectrum of topical therapies to surgical and light-based procedures — but, similar to other medical conditions, they each have their own pros and cons. Arthur Pias Salgueiro, Luciano Henrique de Jesus, Isadora Follak de Souza, Pantelis Varvaki Rados and Fernanda Visioli, Treatment of actinic cheilitis: a systematic review, Clinical Oral Investigations, 10.1007/s00784-019-02895-z, (2019). Cryosurgery is a simple procedure that can be performed to effectively treat localized actinic damage. Epub 2020 Mar 10. -, Dermatol Surg. Br J Dermatol. You should see a doctor if you notice this type of patch on your lip. Treatments of actinic cheilitis: A systematic review of the literature. NIH 2. Actinic cheilitis also describes lip involvement in actinic prurigo, a rare form of photosensitivity. Actinic cheilitis (AC) is a lip inflammation caused by long-term sunlight exposure. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 3.Actinic Cheilitis: Actinic Cheilitis is dryness with thickening of lip.It is caused by excessive exposure to the sun. Treatment of actinic cheilitis by photodynamic therapy with 5-aminolevulinic acid and blue light activation.  |  Gupta AK, Paquet M, Villanueva E, Brintnell W. Cochrane Database Syst Rev. USA.gov. There are several potential treatment options for actinic cheilitis, depending on the severity, such as: ryotherapy (freezing) Topical therapies (e.g., fluorouracil or imiquimod) J Am Acad Dermatol 2020; 83:876. Only a limited number of patients were treated with other therapies, with the exception of PDT, with 68.9% complete responses and 12.6% of recurrences. Please enable it to take advantage of the complete set of features! 1999 Aug;88(2):181-6 No large studies have defined the best treatment of actinic cheilitis.  |  doi: 10.4317/jced.57013. Copyright © 2019 American Academy of Dermatology, Inc. It works by removing the surface layer of the skin. Limitations: Would you like email updates of new search results? A physician may also recommend destruction (ablation) of the damaged cells with carbon dioxide laser in less extreme cases. Actinic Keratosis Natural Treatments include Virgin Coconut Oil, Apple Cider Vinegar, Green Tea, Milk Thistle and Dietary modifications. Lai M, Pampena R, Cornacchia L, et al. The following therapies were recorded in order of frequency: laser therapy, photodynamic therapy (PDT), 3% diclofenac in 2.5% hyaluronic acid, PDT + 5% imiquimod, aminolevulinic acid-laser or methyl-aminolevulinic acid-laser, 5% imiquimod, fluorouracil, partial surgery, 0.015% ingenol mebutate, 50% trichloroacetic acid, and laser + PDT. Other symptoms of Stage 3 include the appearance of evident lesions at the corners of your mouth. 1992 Nov;27(5 Pt 1):737-40 2013 Aug;169(2):250-9. doi: 10.1111/bjd.12343. 2012 Dec 12;12(12):CD004415. HHS Electrosurgery is an alternate treatment, but local anesthesia is required, making it less practical than cryosurgery. OBJECTIVES: Actinic cheilitis is a potentially malignant disorder caused by excessive sun exposure. Among the chemotherapeutic agents assessed, imiquimod showed the best results: clinical improvement in 80 to 100% of the patients, and histopathological improvement in 73 to 100%. actinic cheilitis; diclofenac; imiquimod; laser; photodynamic therapy; treatment. A total of 29 journal articles were selected, and the results were divided according to the type of treatment employed: laser therapy, chemotherapy agents, surgical treatment, and application of anti-inflammatory agents. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Most likely the … Epub 2018 Aug 15. doi: 10.1016/j.adaj.2019.06.025. If the case is severe but there is no evidence of malignancy a lip shave procedure, referred to as a vermilionectomy may be done. Lai M, Pampena R, Cornacchia L, Pellacani G, Peris K, Longo C. J Am Acad Dermatol. Regarding studies describing surgical approaches, the main focus was the search for the best technique, rather than the cure of AC. Clipboard, Search History, and several other advanced features are temporarily unavailable. Other names for it are perleche and angular stomatitis. Actinic cheilitis can be prevented by protecting the lips from sun exposure. For treating and alleviating the pain, rubbing aloe vera on the cracked corners of the mouth also proves to be helpful. As with actinic keratoses, it is widely accepted that this lesion is due to excessive sun exposure ( Glogau, 2000 ). Actinic cheilitis is difficult to treat because surgical treatments have significant adverse effects whereas less invasive procedures have uncertain efficacy. COVID-19 is an emerging, rapidly evolving situation. Laser therapy appears the best option among nonsurgical approaches for actinic cheilitis, and PDT showed higher efficacy when sequentially combined with 5% imiquimod. 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